Preheat oven to 350 degrees F. Generously spray loaf pan with cooking spray.
Combine flour, baking powder and salt. Set aside.
In the bowl of standing mixer, combine lemon zest and granulated sugar, rubbing together with your fingers to extract the essential lemon oils into the sugar.
Attach bowl to standing mixer with paddle attachment. While mixer is running, add melted butter to lemon sugar mix until smooth and light.
Add the Greek yogurt, lemon juice and then the eggs. Stop mixer and scrape down the sides of the bowl to ensure all ingredients are well combined. Keep mixing if needed.
Remove bowl from mixer and gently fold in dry ingredients. DO NOT OVER MIX! The batter will get thick but just ensure everything is loosely combined.
Gently fold in blueberries. Pour the batter into the prepared loaf pan and gently tap on counter to smooth out. Bake for approximately 40-45 minutes or until a toothpick inserted in the center comes out clean.
Place the loaf on a cooling rack and allow to cool completely. Make the glaze while loaf is cooling.
Whisk together the powdered sugar, heavy cream, lemon juice and reserved zest until smooth.
When the loaf is almost completely cooked, pour the lemon glaze on top.
Loaf can be stored in the refrigerator, tightly wrapped, for up to a week or up to 3 months in the freezer.